Dementia and statins
نویسندگان
چکیده
منابع مشابه
Statins and the prevention of dementia.
the population over the age of 65 years. In a multicentre, cross-sectional analysis that examined the relation between treatment with statins and Alzheimer’s disease, it was reported that patients who received lovastatin or pravastatin, but not simvastatin, had a prevalence of the disease that was 70% lower than that found in a control group. In another case–control study, individuals aged 50 y...
متن کاملStatins and the risk of dementia.
BACKGROUND Dementia affects an estimated 10% of the population older than 65 years. Because vascular and lipid-related mechanisms are thought to have a role in the pathogenesis of Alzheimer's disease and vascular dementia, we did an epidemiological study of the potential effect of HMGCoA (3 hydroxy-3methylglutaryl-coenzyme A) reductase inhibitors (statins) and other lipid-lowering agents on dem...
متن کاملImpairment without Dementia in a Cohort Study Use of Statins and Incidence of Dementia and Cognitive
2009;72;1190-1191 Neurology Kalbfleisch, K. Langa and S. Galea Mark R. Goldstein, Luca Mascitelli, Francesca Pezzetta, M.N. Haan, C. Cramer, J. IMPAIRMENT WITHOUT DEMENTIA IN A COHORT STUDY USE OF STATINS AND INCIDENCE OF DEMENTIA AND COGNITIVE This information is current as of April 6, 2009 http://www.neurology.org/cgi/content/full/72/13/1190 located on the World Wide Web at: The online versio...
متن کاملUse of statins and incidence of dementia and cognitive impairment without dementia in a cohort study.
OBJECTIVE Evidence of a relation between use of lipid lowering drugs and cognitive outcomes is mixed. This study aimed to test the association between use of statins and incidence of dementia and cognitive impairment without dementia (CIND) over 5 years of follow-up. METHODS Data were from a population-based cohort study comprising 1,789 older Mexican Americans. All participants had cognitive...
متن کاملCholesterol-independent effects of statins and new therapeutic targets: ischemic stroke and dementia.
The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or "statins", are used as cholesterol-lowering agents worldwide. Statins inhibit cholesterol biosynthesis, leading to enhanced uptake of low-density lipoprotein (LDL) from the circulation via LDL receptors. This strong cholesterol-lowering action contributes to the beneficial effects of statins. For example, large clinica...
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ژورنال
عنوان ژورنال: The Lancet
سال: 2001
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(00)04187-8